Cerefolin NAC Review

by Pan American Laboratories, Inc
Cerefolin NAC
7.68 out of 10 based on 67 user ratings
Cerefolin NAC
Cerefolin NAC
Written by: Brain Research Supplements
Date Published: 2011-06-17
Cerefolin NAC is a prescription medication designed to help people who suffer from beginning stages of memory loss. As it is a prescription medication, it requires a physician’s prescription in the United States. Cerefolin NAC is listed as a medical dietary supplement, and its intended use is to aid in slowing down memory loss.
7.68 / 10 stars
Cerefolin NAC  Review

Cerefolin NAC is a prescription medication designed to help people who suffer from beginning stages of memory loss. As it is a prescription medication, it requires a physician’s prescription in the United States. Cerefolin NAC is listed as a medical dietary supplement, and its intended use is to aid in slowing down memory loss.

Is Cerefolin NAC Right For You?

Cerefolin NAC is a prescription medication designed to help patients who are diagnosed with early stages of memory loss, particularly people exposed to neurovascular oxidative stress and high levels of homocysteine in the blood.

The company behind this product is Pamlab (Pan American Laboratories), the very same company that also produces two other well-known prescription drugs: Deplin and Metanx. Pamlab was founded in 1957, and it has an excellent track record. The good reputation of this manufacturer and the lack of contrary evidence regarding the marketed products, manufacturing technologies, and/or the quality of ingredients used has convinced us that this is one of the leading producers in the healthcare industry.

However, Cerefolin NAC is a prescription medication, which means in the United States it is only sold when recommended by a physician. This drug is listed as a “medical dietary supplement, in” and its intended use may include alleviating or slowing down symptoms of vascular dementia, Alzheimer’s disease, and mild to moderate cognitive impairment linked or not to a deficiency in Vitamin B12.

Certain research studies seem to present the formula as a rather effective therapy against various memory and thinking problems, low energy levels, and a minimal sense of well-being. However, the full extent of Cerefolin NAC side effects, benefits, and precautions is still under research.

According to the manufacturer, this prescription drug works by providing the body with Folate, Vitamin B12, and a form of antioxidant called N-acetylcysteine. Cerefolin NAC ingredients are described to “work synergistically to reduce or eliminate oxidative stress and lower homocysteine levels.”

Please keep in mind that Cerefolin NAC is a prescription drug and it may not be recommended for some medical conditions. We strongly advise patients to talk to their doctor or pharmacist before taking this medication.

Ingredients of Cerefolin NAC

Cerefolin NAC includes the following ingredients: L-methylfolate 5.6 mg, Methylcobalamin 2 mg, N-acetylcysteine 600 mg, microcrystalline cellulose, opadry (Hypromellose), talc, titanium dioxide, polyethylene glycol, saccharin sodium, and magnesium stearate (vegetable source).

Cerefolin NAC
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67 User Reviews or Add One about Cerefolin NAC Review

  1. 1

    Has anyone used this supplement for depression? My young daughter has been prescribed this med, and I would like to find out if this is effective on younger patients for mental focus and general well being.

  2. 2

    Theresa Semona


    I am 70yo, at age 67 had TBI with brain bleed. My neurophyscologist rec. CEREFOLIN. This review mentioned that there are better ways to improve memory, as still suffer effects of this injury tho taking Cerefolin. But did not state what they might be.

    • 3

      Theresa Semona


      Posted a comment in Oct. Am a 70 yr woman with a TBI. I didn’t renew my Cerefolin Rx, just to see if I noticed a difference. There is a huge difference, my short term memory is terrible, way worse than when on Cerefolin, also I am not sleeping as well, feel generally foggy, indecisive, definitely have lost the feeling of wellbeing I did have. Have had my Rx renewed, just waiting for it to arrive. Will be interesting to evaluate the change once I am back on it.

  3. 4

    I had been taking Cerefolin NAC for a year and found some improvement of memory and thought process when my insurance company refused to refill. I was told the cost to me would be 300.00. I was given the prescription from my psychiatrist, Dr. Matthew Pitera after I had complained of memory loss – difficulty finding my words. I have been treated for depression over the years and this was so trying for me. The Cerefolin helped but I cannot afford to pay out of pocket. Please consider helping me with this.
    Jill Sweet

  4. 5

    I took his for a while since I had free samples. I stopped them and replicated the 3 main ingredients with OTC vitamin products. I saw my neurologist today, 2 years later and he insists the difference is that the product crosses the blood brain barrier. When I asked how it did that vs the supplements I’d been taking he claimed because they are fat soluble and mine aren’t. That doesn’t make sense to me because a supplement is fat soluble or water soluble. I know you can get water soluble vitamin A for example but how do you get a water soluble vitamin to be fat soluble? And is that really what they’ve done?
    I’ve had 7 concussions and want to know before I start taking it. Sounds fishy :)

    • 6

      I do not think that the lipid or water solubility is the problem. Literature indicates that around 50% of people lack the enzyme that converst folic acid to L-methylfolate. L-methyl folate is the active metabolite that is able to cross the blood-brain barrier. It is then transformed into seratonin and other neurotransmitters that make you feel better. There is L-methylfolate and R-methylfolate (Mirror images of each other (left and right). Only the left form has the right spatial configuration to pass thru the blood brain barrier. Think of a puzzle…. only one piece will fit in that hole. In this case it is the l-methylfolate configuration. The blood brain barrier protects you brain from many toxic chemicals by not letting them be transported into the brain. All you can do is take it for a while and see if you feel better.

    • 7

      Diane, The doctor is right. Google fat soluble and water soluble. I take anxiety and depression meds that pass the blood brain barrier. Means it goes straight to my brain.

  5. 8

    My father-in-law was assessed by a neurologist for dementia or Alzheimer’s. I had read that dementia could be caused by a vitamin deficiency. The neurologist ran blood tests, did testing regarding short term memory and long term memory. After evaluation, the neurologist prescribed Cerefolin NAC and took my father-in-law off of two other medications.

    Within a week, we started to notice improvement. It’s now been 4 months and my father-in-law is back to how he was years ago!

    Note – things like surgery, other prescription medication and stress can have an effect on your glutathione levels. These can also be affected by an underlying genetic polymorphism. If you want to know more, start looking at things like methylation pathway and micronutrient level testing.

  6. 9

    I have been taking Cerefolin for almost 6 months now. I am 50 yrs young, had a hysterectomy in my 30s and have been both hyper and hypothyroid.
    I work full time and have lots of stress in my work and personal life. Thank goodness for my Doctor, she is the reason I take Cerefolin and other important vitamins. I tested positive for the MTHFR gene mutation too.
    I also take methyl B12, a coenzymated B and multi vitamin. I have to say I also quit sugar 3 months ago!! No to very little white flour products ever. My health, energy levels and mood have all benefited beyond my expectations. This should be 5 stars.

    • 10

      Mary, I give you lots of credit. I totally understand how chaotic your life is. I’m in a similar situation. I turn 50 in a couple of months and I have MS, asthma, Sjrogrens and allergies. I have 4 grown children and 2 grandchildren. I lost my NY job a year ago, and along with it went my salary. I’m building my business (Medicaid and Estate Planning) with a partner and working 3/4 time as a paralegal. I had been taking Cerefolin for a long time, but I had to give it up when I lost my job. I’m not starting it again – God willing

  7. 11

    Dee Ernst


    I tried to rate this a five. It helped me with a foggy feeling, word retrieval and anxiety. I took it for several months and if made a huge difference. I recently stopped taking it and my problems have returned. I started taking again, I hope it works quickly. Oh, the folic acid is not like what you can buy in a store. This product is specifically formulated to cross the blood brain barrier. Good luck!

  8. 12

    Sharon La Barbera


    I read in one of the comments that Cerefolin contains soy, Is this true? I have had breast cancer and should not take any soy products. Thx

  9. 14

    Just started on this medicine but am now concerned that it may help to produce Kidney Stones. Is this a possibility? I have heard that it does happen. If so, I do not want to continue taking it.

    • 15



      In the clinical studies published, none of the patients experienced kidney stones. Side effects are similar to placebo (or a sugar pill).

  10. 16

    I’m waiting to receive my prescription. My Dr tested my B levels and found that I was very deficient. I am 49, a professional with a stressful job. I also had a hysterectomy in my 30s. I really sincerely hope this will help me. My memory hasn’t been up to par and it’s driving me nuts.

  11. 17

    my wife is 91 and started taking Cerefolin NAC about 2 weeks ago for memory. Seems to work and is no longer irate. Memory has improved. I am 90 and have some memory loss. I better check it out

  12. 18

    I was given this medical food by my doctor I have concerns about some of the ingredients:soy,I titanium dioxide,polyvinyl alcohol,red color. Is it safe to consume these ingredients on a regular basis ?

  13. 20

    Charles Robinson


    Fantastic drug, without it I would now be in an institution. Life is good, I’ve been on this drug for 12 years, stopped once, what a mistake. However, the price could come down a lot.

  14. 21

    I have a question. I just started taking Cerefolin NAC today. It was prescribed for me because I lost my sense of smell and taste 5 months ago after having an upper respiratory infection. Has anyone else used it for this readon, and if so was it helpful?

    • 22

      I started taking this drug 7 days ago after 7 months of burning mouth syndrome with loss of taste. Yesterday I realized I could taste again. Today I am almost back to normal. For the first time in months, I can taste sweets! However, I am hungry all the time. That may not be a good thing. Burning mouth still there, but not as severe…. “small steps”
      Good luck. Hope it works for you.

  15. 23

    Simona K.


    I love how Cerefolin NAC makes me think more clearly, stay focused for longer periods of time and how it helps with my memory in general. I am very satisfied with this product and I think it is one of the best cognitive enhancers I tried so far.

  16. 24

    Diane F.


    We bought this for my mother who was becoming forgetful. We went to a doctor and had her tested for Alzheimer’s disease, but he said it’s not Alzheimer’s and that is only normal for memory loss after a certain age (my mother was 61 years old at the time). He prescribed Cerefolin-NAC and she started the treatment a few days after. We started noticing improvements in her mental state after the first 2 months and she’s been under this medication for over 6 months with no serious side effects so far. This is a very good product and I believe it’s worth every penny.

  17. 25



    After an exam from my Dr. For some slight memory loss she gave me a 4 week supply of this medication and had me check in for a follow up. After 2 weeks I noticed an improvement in my remembering things and really started to feel better. I have found that not many smaller pharmacies carry it or the generic. Its been 4 weeks waiting for shipments to come in. Thank goodness the dr had samples.
    I do have an inquiry about cerefolin nac, and sarcoidosis. My son has sarcoidosis and has noticed his memory is starting to fail. Is this a medication that would be beneficial for him to try out?

  18. 26

    I started having issues with my memory, feeling like I was walking in a fog, and stuttering. I am a professional and my job is very stressful. I didn’t know how this came about except that I was starting menopause. On top of everything else, due to my hectic schedule, I don’t eat right. I went to my doctor and thought I had a stroke, early Alzheimer’s or just losing my mind. He took various tests to rule out any physical issues and prescribed Cerefolin NAC in 2013. I started feeling better after two days of taking the pills. I felt much better, the fog was gone, and the stuttering was gone. My family noticed the difference.

    I wondered if it was really the Cerefolin NAC, that made the difference, so I stopped taking it for a few days. Sure enough, I slowly started stuttering again, it was difficult to concentrate, and the fog was slowly coming back. My mother asked me if I was taking my medicine, because I am stuttering more and it’s taking me more time to remember things. I started taking Cerefolin NAC again and the above issues went away again.

    I will say that you may have to either have someone monitor you to see if things change or make a mental note of your issues before taking the medicine. The reason I say this is because you may or may not realize you’re better, because the results don’t hit you like a cannon, it’s mild and you just feel normal (in a good way). For instance, after I started taking the medicine again and during a conversation with my mom, she said, you’re taking the medicine again. I asked her how she knew, she said, you aren’t stuttering, it’s not taking a long time for you to ‘find the right word’ in a normal conversation and it’s just a smooth conversation.

    The downside is the price and my insurance will not cover it. At tax time, I add this in my itemization. I see from another post here that we can buy the main ingredients separately without the fillers. I just ordered my next supply of Cerefolin NAC. from Brand Direct Pharmacy online (they seemed to be the cheapest). I may try buying the three ingredients next time.

    • 27

      thanks for sharing your story. I’m a male and I started to feel like the way you were feel like 3 to 4 weeks ago. I just started today on 10/1/15. I hope this helps because I also work because I’m a professional w a very detail job. When did you take the pill in the morning or afternoon. Thanks jose d

    • 28

      Hi I read alot of these replies and it seems alot of you who are on it are older…my specialist put me on it last week n I m only 41…this worries me…I am on it for memory loss , brain fog, stuttering short term loss n concentration problems…all from a horrible incurable disease…does anyone have side effects with this medicine??

      • 29

        I was diagnosed at age 35 with clinical depression and anxiety disorder. My psychiatrist prescribed Cerefolin NAC along with sertraline (Zoloft) and clonazepam. After taking the sertraline for awhile I described to her a zombie-like feeling: walking in a cloud, being in conversations but not feeling as if I was part of the conversation, slowness in recalling words, not remembering past events, people, etc., all of the symptoms described here. She prescribed Cerefolin NAC, which made a noticeable difference, and she kept me on it after changing my anti-depressant, which is now Viibryd. I am now 58 and my psychiatrist has retired. My primary care physician has agreed to oversee my meds until I find another psychiatrist. Recently my insurance company stopped covering Cerefolin NAC. (By the way, in the past pharmacists have told me I could just buy folic acid OTC instead. My psychiatrist gave me an article to give to my pharmacist to educate him on the differences). Without the ins coverage I quit taking Cerefolin. I have been feeling more anxious and depressed recently and all of the other symptoms I mentioned have worsened. I asked myself what has changed and thought of the Cerefolin, looked it up online, read several articles, but it wasn’t until I happened onto this site and read these posts that it hit me like a ton of bricks!!! The posts here have confirmed what I had been taking for granted in the Cerefolin. I am posting here to Lisa specifically b/c of your concern about the oler ages of those taking Cerefolin. Though I’m 58 now, I consider myself young, too, when I first started talking it. I realize today that I must start taking it again, even if I have to pay for it out-of-pocket. Few people, including my PCP know what it is, how it works, or what it does. Thanks to all of the posters here, I think for the first time in the years I’ve been taking it I truly understand its effects. I think you have provided the missing piece of the puzzle that will get me back to the quality of life I had previously been enjoying. Thanks, and keep posting!

      • 30



        Studies show no adverse side effects, and are similar to placebo (or a sugar pill). Safe and well tolerated.

  19. 31

    Before any of you invest in Cerefolin it would pay you to check the ingredients without the fillers. There are only three: 5.6mg Methylfolace, 2mg Vit.B12, and 600mg N-Acetyl Cysteine. My granddaugther who is a licenced chemist checked this for me and I was able to purchase these ingredients separtely at a vitamin shop for about a quarter what Cerefolin costs. Check it out.

      • 33



        Cerefolin NAC contains the most bio-available forms of these 3 ingredients. Not the synthetic forms found over the counter or at vitamin stores. This is prescription grade, FDA regulated, clinically proven and contains Metafolin (which is the companies branded version of L-Methylfolate) that has been clinically proven in over 25 clinical trials. This cannot be replicated. Over the counter products will not provide the same outcome as they have to go through the body’s methylazation cycle.

  20. 34

    My husband had a hemorrhagic stroke 2 years ago. His phd psychologist put him on Cerefolin NAC. I can’t tell if it helps because I’ve never seen him off of it. The literature says it’s for neurovascular oxidative stress. I hate to keep using something that is expensive if it’s not been FDA tested and is just touted as “brain food.” I realize it may help those with memory loss, but I’d like to know from other stroke patients if it has helped them and from doctors who might have information about it. It has folate, B12, B2, B6 and an anti-oxident called N-acetylcysteine. I suppose folate is the same is folic acid that pregnant women use? I’m not sure. If anyone besides the Cerefolin company can give some advice on this, I would appreciate it. Thanks.

    • 35

      Your husband was given an excellent medication. I had a stroke years ago and had to go several years with not only memory problems, but also paranoia. Those problems finally subsided. More recently I had abdominal surgery where I was placed on a 60 degree downslope operation table. For a month afterwards my memory was so bad it scared me. My family physician put me on Cerefolin NAC and within three days I felt that I was back to normal. I am so grateful!!! I am still taking the medication and will continue to do so until I feel confidant enough to do without it.
      Good luck to your husband. Give him your love. Let him continue to take his meds. He will discontinue when he is ready.

  21. 36



    Alzheimer disease is an unfortunate fact in our family, my mother, her mother and two of her brothers, so far, suffer/suffered from this disease. As the eldest in the next generation I have noticed frightening cognitive difficulties. Also a side effect of other medications resulted in Vertigo and further memory loss. My family practice doctor just prescribed CerefolinNac a week ago and I will report to him how I am responding to it in another week. I am sure that in time I will see major good effects since it does seem to be helping already. I have confidence in this prescription because my doctor plays drums at his church so he takes it for his inner ear.

  22. 37

    I hope I don’t say things that are untrue. I am a bit of a hypochondriac and sometimes exaggerate with medication. However, a year ago I have started to forget various details in my daily life. My mother convinced me it was nothing important, but it started to get more and more annoying. When I finally decided to try Cerefolin-NAC I did it against the will of my mother. It was the best decision of my life. In a couple of months I was back to my former self.

  23. 38



    I have bought this for my grandma as she was starting to forget common things. This formula helped her to remember more important things than she used to lately. I am grateful to her doctor that prescribed her the perfect drug.

  24. 39

    Emma D.


    My doctor prescribed me Cerefolin for short term memory loss. I took this medicine for more than 2 months, but I didn’t notice any result by now. I will continue to use it for one more month and if it doesn’t work, I will consider changing my medication.

  25. 40

    I’m confident that this pill is keeping my condition in check. At first I got scared and I thought that I will be a living vegetable in no time. The doctor reassured me that it will be ok as long as I take my medication and prescribed me Cerefolin. It’s been a year now and everything seems to be normal.

  26. 41

    Bert is my name and I received a prescription for Cerefolin NAC about three months ago. I hesitated to start the treatment but my wife convinced me that I forget way to many things. Now there is little difference, but I may be judging it too fast. I see a lot of people that have used it for longer periods of time.

  27. 42

    This medicine was prescribed to me six months ago. I did not recover anything that I lost prior to my treatment. Fortunately, i did not lose anything either. The sad thing is that I’m going to have to take this for the rest of my life, but I guess I can live with that.

  28. 43

    My grandmother started forgetting things more often than usual. The doctor recommended her Cerefolin NAC. Hopefully it will work, cause I want my grandma back! She only took it for 2 weeks! I will keep you updated!

  29. 44

    Taking this drug has saved me from having to switch jobs. Even if it gives me only a couple more years at my current one, the money I gather in that time is priceless for me and my family. I was lucky that my doctor prescribed me this.

  30. 45

    My doctor told me to take this medicine because I was starting to forget a lot if important information. I don’t know if this is a sign for a more dangerous condition, but I din’t think it was, because while I’m taking this i start remembering things again.

  31. 46

    I’ve been prescribed this six months ago. At first I did not feel any solid improvements but my doctor insisted I would continue to take it because it is a long term treatment. After three months I noticed I was starting to forget less and less things in my daily routine. I really think it’s doing it job properly.

  32. 47



    Since I turned sixty I gradually started to lose focus and I often forgot more and more everyday things. I started to worry that I might a serious disease, but my doctor told me that it’s probably a stress related issue amplified by my age. He gave me a list of supplements that might help me and I chose Cerefolin because I heard many people are using it. Although I occasionally forget a few things, I feel a lot more in control and no longer worry about it.

  33. 48



    This drug helped my grandfather with his memory loss and also improved his mental clarity. We are so grateful to his doctor for recommending it to us two years ago. And so far, grandpa didn’t experience any side effect besides mild headaches now and then which I understand are very common with this type of medication.

  34. 49

    I use it for stress-related memory issues and it works like a charm. I felt like the way it performs, even at the beginning of the treatment.

  35. 50

    My sixty year old mother is using this to prevent further memory loss and so far it’s working. I truly hope it will keep working, otherwise it would sadden me greatly.

  36. 51

    I’ve started on Cerefolin NAC about six months ago and I can certainly see some improvements. However my GP told me two days ago that I now have kidney stones and he thinks it’s because of Cerefolin. Has anyone had this problem?

  37. 52

    mike daniels


    My dad started to have these memory losses some months ago. His doctor said that this was caused by his sleeping pills and told us to give him Cerefolin NAC. It really worked.

  38. 53

    hart parris


    I was prescribed this medication for RLS and have been surprised by the results. At 63, my memory certainly isn’t what it was, still I have noticed a clarity of thought and slight feeling of euphoria after I take the pill. I very much wanted to get off the Requip and now think I will be able to do that. I may even start weaning myself off my anti=anxiety as well.

  39. 54

    Victor S.


    My doctor prescribed Cerefolin NAC as I was found with high levels with homocysteine in the blood which increases the risk of a heart attack. I took this treatment for 6 months and repeated the tests. The homocysteine levels are back to normal. Of course, I also had to make a change in my feeding habits and exercised more, but I really think that the medication had an important role in the process.

  40. 55



    Because my mother had Alzhiemer’s, I am constantly concerned that I might succumb to the illness as well. I have been taking Cerefolin for about 4 months as a hopeful hedge against the disease. In reading the information above, I noticed that it suggested a better option “amino acids supplementation that also contains the needed neuro-nutrients that your brain demands”. I am curious what product that might be.
    Thank you,
    S. Barnes

  41. 57

    My daughter was failing her classes in college after being an honor student for 10 years due to memory. She could not retain information, and even forgot she had an online cleass one semester. We got her a medical withdrawl and this is one of the medication her Dr. put her on. The other is Phosphatidyl Serine. It has helped her alot, and she notices a huge difference if she misses a day, Her depression has lifted, and she is sleeping much better and is finding it easier to get out of bed in the mornings. I would recommend trying this knowing the pain and frustration she went through.

  42. 58

    This helped me to get my brain back. I take a medicine for epilepsy that lowers the amount of folate in the brain, causing side effects such as word finding difficulty – literally you cannot think of simple words like chair for example, a feeling of fogginess and short term memory issues. Three weeks after taking this my mind just suddenly clicked!! A few months later my doctor upped my dose. So if this doesn’t work for you after a month, ask to have your dose increased. I’m so thankful for this medication, one with zero side effects to boot!

    • 60

      Right after entering menopause, I noticed that I was having trouble with word association much like you, Emily. I would see a chair, could describe it as a piece of furniture that you sit on, but could not think of the word “chair”. This was an on and off again problem. Some days were worse than others. My doctor prescribed Cerefolin and I have notice a really big difference! It took about a month to see the biggest gains, but as long as I take it, my word association problems have virtually disappeared. This was truly a life saver for me!

    • 62

      Hi Emily

      I noticed your post in reference to your use of Cerefolin in 2011, by chance are you still taking the medication? If so, what would say are the benefits, or changes you have experienced.

      I look forward to your response.

      Thank you

  43. 63

    Dan Glickman


    This medicine did not help at all. I did not see a bit of difference in my sons behavior. It did not help him concentrate more at all.

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